2014

Susanne H Hodgson, Prateek Choudhary, Sean C Elias, Kathryn H Milne,1 Thomas W Rampling, Sumi Biswas, Ian D Poulton, Kazutoyo Miura, Alexander D Douglas, Daniel GW Alanine, Joseph J Illingworth, Simone C de Cassan, Daming Zhu, Alfredo Nicosia, Carole A Long, Sarah Moyle, Eleanor Berrie, Alison M Lawrie, Yimin Wu, Ruth D Ellis, Adrian V S Hill, Simon J Draper.  Combining Viral Vectored and Protein-in-adjuvant Vaccines Against the Blood-stage Malaria Antigen AMA1: Report on a Phase 1a Clinical Trial.   Mol Ther v.22(12); 2014 Dec PMC4250079 (EMVDA)

Sloot R, Schim van der Loeff M, van Zwet EW, Haks M, Keizer ST, Scholing M, Ottenhoff THM, Borgdorff MW, Joosten SA Biomarkers can identify pulmonary tuberculosis in HIV-infected drug users months prior to clinical diagnosis. EBioMedicine (2014) doi: 10.1016/j.ebiom.2014.12.001 (IDEA)

Salim N, Schindler T, Abdul U, Rothen J, Genton B, Lweno O, Mohammed AS, Masimba J, Kwaba D, Abdulla S, Tanner M, Daubenberger C, Knopp S Enterobiasis and strongyloidiasis and associated co-infections and morbidity markers in infants, preschool- and school-aged children from rural coastal Tanzania: a cross-sectional study. BMC Infectious Diseases. 2014 Dec 9;14(1):644. (IDEA)

Eoghan de Barra, Susanne H. Hodgson, Katie J. Ewer, Carly M. Bliss, Kerrie Hennigan, Ann Collins, Eleanor Berrie, Alison M. Lawrie, Sarah C. Gilbert, Alfredo Nicosia, Samuel J. McConkey, Adrian V. S. Hill.  A Phase Ia Study to Assess the Safety and Immunogenicity of New Malaria Vaccine Candidates ChAd63 CS Administered Alone and with MVA CS.  PLOS one DOI:10.1371/journal.pone.0115161 December 18, 2014 (CSVAC)

Odile LeroyMark GeelsJoanna Korejwo, Betty Dodet, Nathalie ImbaultStefan Jungblut.  Roadmap for the establishment of a European vaccine R&D infrastructure. Vaccine 32, issue 51, 5 December 2014, pages 7021 - 7024 (TRANSVAC)

C. Dutruel, J. Thole, M. Geels, H. Mollenkopf, T, Ottenhoff, C.A. Guzman, H.A. Fletcher,O. Leroy, S.H.E. Kaufmann. TRANSVAC workshop on standardisation and harmonisation of analysis platforms for HIV, TB and malaria vaccines. ‘How can big data help?’. Vaccine, 32, issue 35, 31 July 2014, 4365 - 4368 (TRANSVAC)

Schwarz A, Tenzer S, Hackenberg M, Erhart J, Gerhold-Ay A, Mazur J, Kuharev J, Ribeiro JM, Kotsyfakis M.  A systems level analysis reveals transcriptomic and proteomic complexity in Ixodes ricinus midgut and salivary glands during early attachment and feeding.  Mol Cell Proteomics. 2014 Oct;13(10):2725-35. doi: 10.1074/mcp.M114.039289. Epub 2014 Jul 21 (TRANSVAC)

Sanchez MV, Ebensen T, Schulze K, Cargnelutti D, Blazejewska P, Scodeller EA, Guzmán CA.  Intranasal delivery of influenza rNP adjuvanted with c-di-AMP induces strong humoral and cellular immune responses and provides protection against virus challenge. PLoS One. 2014 Aug 20;9(8):e104824. doi: 10.1371/journal.pone.0104824. eCollection 2014 (TRANSVAC)

Katherine E. Wright, Kathryn A. Hjerrild, Jonathan Bartlett, Alexander D. Douglas, Jing Jin, Rebecca E. Brown, Joseph J. Illingworth, Rebecca Ashfield, Stine B. Clemmensen, Willem A. de Jongh, Simon J. Draper, & Matthew K. Higgins.  Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies. Nature doi: 10.1038/Nature 13715 (InnoMalVac)

Afolabi MO, Adetifa JU, Imoukhuede EB, Viebig NK, Kampmann B, Bojang K.  Earlyphase clinical trials with human immunodeficiency virus-1 and malaria vectored vaccines in The Gambia: frontline challenges in study design and implementation. Am J Trop Med Hyg. 2014 May; 90(5): 908-14. doi: 10.4269/ajtmh.13-0615 (MVVC)

Nébié I, Edwards NJ, Tiono AB, Ewer KJ, Sanou GS, Soulama I, Sanon S, Diarra A, Yaro JB, Kangoye D, Imoukhuede EB, Hill AV, Sirima SB.  Assessment of chimpanzee adenovirus serotype 63 neutralizing antibodies prior to evaluation of a candidate malaria vaccine regimen based on viral vectors. Clin Vaccine Immunol. 2014 Jun; 21 (6): 901-3. doi: 10.1128/CVI.00723-13 (MVVC)

Kimani D, Jagne YJ, Cox M, Kimani E, Bliss CM, Gitau E, Ogwang C, Afolabi MO, Bowyer G, Collins KA, Edwards N, Hodgson SH, Duncan CJ, Spencer AJ, Knight MG, Drammeh A, Anagnostou NA, Berrie E, Moyle S, Gilbert SC, Soipei P, Okebe J, Colloca R, Viebig NK, Roberts R, Lawrie AM, Nicosia A, Imoukhuede EB, Bejon P, Chilengi R, Bojang K, Flanagan KI, Hill AV, Urban BC, Ewer KJ.  Translating the immunogenicity of prime-boost immunisation with ChAd63 and MVA ME-TRAP from malaria naïve to malaria-endemic populations. Mol Ther. 2014 Jun 16. doi: 10.1038/mt.2014.109 (MVVC)

Sean C Elias, Prateek Choudhary, Simone C de Cassan, Sumi Biswas, Katharine A Collins, Fenella D Halstead, Carly M Bliss, Katie J Ewer, Susanne H Hodgson, Christopher J A Duncan, Adrian V S Hill, Simon J Draper.  Analysis of human B-cell responses following ChAd63-MVA MSP1 and AMA1. Immunization and controlled malaria infection. Immunology. 2014 Apr; 141(4): 628–644 (EMVDA)

Afolabi MO, Okebe JU, McGrath N, Larson HJ, Bojang K, Chandramohan D.  Informed consent comprehension in African research settings. Trop Med Int Health. 2014 Jun;19(6):625-642. doi: 10.1111/tmi.12288. Epub 2014 Mar 17 (MVVC)

Afolabi MO, Bojang K, D’Alessandro U, Imoukhuede EB, Ravinetto MR, Larson JH, McGrath N, Chandramohan D.  Multimedia informed consent tool for a low literacy African research population: Development and pilot-testing. Journal of Clinical Research and Bioethics. 2014;5(3):178.doi:10.4172/2155-9627.1000178 (MVVC)

Afolabi MO, Bojang K, D’Alessandro U, Ota MOC, Imoukhuede EB, Ravinetto  MR, Larson JH, McGrath N, Chandramohan D.  Digitised audio questionnaire for assessment of informed consent comprehension in a low literacy African research population:  Development and psychometric evaluation. BMJ Open. 2014 4:e004817.doi:10.1136/bmjopen-2014-004817 (MVVC)

Sean C. Murphy, Cornelus C. Hermsen, Alexander D. Douglas, Nick J. Edwards, Ines Petersen, Gary A. Fahle, Matthew Adams, Andrea A. Berry, Zachary P. Billman, Sarah C. Gilbert, Matthew B. Laurens, Odile Leroy, Kristen E. Lyke, Christopher V, Plowe, Annette M. Seilie, Kathleen A. Strauss, Karina Teelen, Adrian V. S. Hill, Robert W. Sauerwein.  External Quality Assurance of Malaria Nucleic Acid Testing for Clinical Trials and Eradication Surveillance. Plos One, vol.9, issue 5, May 2014

Wiebke Nahrendorf, Anja Scholzen, Else M. Bijker , Anne C. Teirlinck, Guido J. H. Bastiaens ,Remko Schats , Cornelus C. Hermsen , Leo G. Visser , Jean Langhorne, Robert W. Sauerwein. Memory B-Cell and Antibody Responses Induced by Plasmodium falciparum Sporozoite Immunization.  J Infec. Dis 2014, vol. 210, issue 12 (EMVDA)

Mkunde Chachage, Lilli Podola, Petra Clowes, Anthony Nsojo, Asli Bauer, Onesmo Mgaya, Dickens Kowour, Guenter Froeschl, Leonard Maboko, Michael Hoelscher, Elmar Saathoff, Christof Geldmacher Helminth-Associated Systemic Immune Activation and HIV Co-receptor Expression: Response to Albendazole/Praziquantel Treatment. PLOS Neglected Tropical Diseases 2014 Mar 27;8(3):e2755. doi: 10.1371 (IDEA)

Knopp S, Salim N, Schindler T, Karagiannis Voules DA, Rothen J, Lweno O, Mohammed AS, Singo R, Benninghoff M, Nsojo AA, Genton B, Daubenberger C. Diagnostic Accuracy of Kato-Katz, FLOTAC, Baermann, and PCR Methods for the Detection of Light-Intensity Hookworm and Strongyloides stercoralis Infections in Tanzania. American Society of Tropical Medicine and Hygiene. 2014 Mar; 90(3):535-45. doi: 10.4269/ajtmh.13-0268. Epub 2014 Jan 20 (IDEA)