SE36 | RH5 | ME-TRAP | R21

MIMVaC-Africa

at a glance

TARGET DISEASE

Malaria | Liver and Blood stage

TIMELINE

01 February 2020 - 31 January 2025

COORDINATOR

GRAS

FUNDER

EDCTP

FUNDING

11.9 Mio Euro

SUMMARY

A multilateral initiative to foster the clinical development of effective malaria vaccine candidates in Africa (MIMVaC-Africa)

The overall objective of the MIMVaC-Africa consortium is to accelerate the development of highly effective malaria vaccines that meet the goals set by the WHO Malaria Vaccine Technology Roadmap. For the first time, vaccines developers, malariologists, trialists from Sub-Saharan Africa, Europe, USA and Asia, are joining forces to comparatively assess malaria vaccine candidates.

Five malaria vaccine candidates will be evaluated including three Pre-erythrocytic vaccine candidates (R21/Matrix-M, the chemically attenuated whole sporozoite vaccine and the METRAP viral vectors) and two Blood-stage candidates (PfRH5/Matrix-M and the NPC-SE36/CpG).

The project will build on the recently developed African controlled human malaria infection (CHMI) challenge model capacity to rapidly test and compare targeted malaria vaccine candidates and down-select the vaccine candidates to be assessed in a phase 2b multicenter clinical trials in African children under natural exposure to P. falciparum infection.

Beyond delivering promising candidate(s) suitable for testing in phase 3 trial(s), it is also expected to i) Strengthen translational vaccine development platform capabilities in African sites, ii) Reinforce the clinical trial infrastructure and iii) Develop immune assays capacity in Africa.

Interaction of EDCTP’s Networks of Excellence from East, South, Central and West Africa will be strengthened and a dialogue will be engaged with regulatory authorities, Ministries of Health, and important local and international stakeholders to facilitate continuous engagement and discuss requirements for expedited deployment of a successful malaria vaccine candidate.

PARTNERS

Groupe de Recherche Action en Santé (GRAS) (Burkina Faso); Eberhard Karls Universität Tübingen (EKUT) (Germany); University of Oxford (UOXF) (UK); Leiden University Medical Center (LUMC) (The Netherlands)
Luxembourg Institute of Health (LIH) (Luxembourg); Osaka University (Japan); Centre de Recherches Médicales de Lambaréné (CERMEL) (Gabon); Fundação Manhiça (Mozambique); Ifakara Health Institute (IHI) (Tanzania)

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