MALARIA 

Malaria

at a glance

Malaria is caused by Plasmodium parasites. The parasites are transmitted to people through the bite of infected female Anopheles mosquitoes. There are five disease-causing Plasmodium species, but P. falciparum is the predominant parasite worldwide, with exception of the Americas where P. vivax accounts for the majority of Malaria cases.

Malaria is an acute febrile illness. Frequent symptoms include fever, chills and headache, if left untreated it can progress to severe manifestations, such as severe anaemia and cerebral malaria. 

Due to global efforts malaria deaths have been reduced by half, since 2010. Still...

Every 2 minutes, a child dies of malaria.

of the world's population is at risk

 ≈ 44%

3.4 Bio in 92 countries

Death rate from malaria

2017

cases annually

228 Mio

in 2018

93%

213 Mio

of all cases occur in Africa

67%

272 000

of all deaths occur in children <5

Malaria is curable and preventable. Methods of prevention include vector control, insecticide-treated nets and Intermittent preventive treatment in pregnant women and infancy. Currently there is no effective vaccine available.

World Malaria Day is celebrated on 25th April, as an opportunity to raise awareness and mobilise political commitment towards Malaria research, control and prevention.

EVI's recent efforts to develop malaria vaccines by building a portfolio that encompasses blood-stage malaria vaccines, including targeting placental malaria,and as well as pre-erythrocytic and combination malaria vaccines:

Malaria Vaccines

Discovery

Pre-clinical proof of concept

Clinical proof of concept

    Phase Ia    

    Phase Ib    

    Phase IIa    

Development

      Phase IIb     

    Phase III   

Multi-stage vaccine

Blood-stage 

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