at a glance
Malaria is caused by Plasmodium parasites. The parasites are transmitted to people through the bite of infected female Anopheles mosquitoes. There are five disease-causing Plasmodium species, but P. falciparum is the predominant parasite worldwide, with exception of the Americas where P. vivax accounts for the majority of Malaria cases.
Malaria is an acute febrile illness. Frequent symptoms include fever, chills and headache, if left untreated it can progress to severe manifestations, such as severe anaemia and cerebral malaria.
Due to global efforts malaria deaths have been reduced by half, since 2010. Still...
Every 2 minutes, a child dies of malaria.
of the world's population is at risk
3.4 Bio in 92 countries
Death rate from malaria
of all cases occur in Africa
of all deaths occur in children <5
Map: adapted from OurWorldInData.org/malaria/
Malaria is curable and preventable. Methods of prevention include vector control, insecticide-treated nets and Intermittent preventive treatment in pregnant women and infancy. Currently there is no effective vaccine available.
World Malaria Day is celebrated on 25th April, as an opportunity to raise awareness and mobilise political commitment towards Malaria research, control and prevention.
EVI's recent efforts to develop malaria vaccines by building a portfolio that encompasses blood-stage malaria vaccines, including targeting placental malaria,and as well as pre-erythrocytic and combination malaria vaccines:
Pre-clinical proof of concept
Clinical proof of concept