P27A sponsored student

Catherine Gerald Mkindi (PhD student)

Supported by the European and Developing Countries' Clinical Trials Partnership (EDCTP) Strategic Primer Grant number: SP_2011_41304_047

Based at: Ifakara Health Institute, Bagamoyo Tanzania and University of Basel (Switzerland)

Supervisor: Dr Claudia Daubenberger, University of Basel

Summary:
Description of malaria peptide P27A specific immune responses delivered with Alhydrogel or GLA-SE in Tanzanian volunteers.

The main objective of the study is:
To evaluate immunogenicity of a novel Plasmodium falciparum synthetic peptide vaccine candidate P27A administered with GLA-SE or Alhydrogel adjuvants against blood stage parasites in malaria exposed Tanzanian adults.

The specific objectives are:

  1. To evaluate induction of P27A specific antibodies and determin their immunoglobulin subclasses.
  2. To determine if produced antibodies inhibit parasite growth in vitro.
  3. To measure P27A specific T cell proliferation in peripheral blood mononuclear cells.
  4. To measure intracellular cytokine production in vaccine induced P27A specific T cells in peripheral blood mononuclear cells.

Catherine Gerald Mkindi was born in Arusha, Tanzania in 1978.  After becoming a Bachelor of Veterinary Medicine at Sokoine University, she completed a Diploma Programme for Agricultural and Natural Resources Transformation for Improved Livelihood at University of Life Sciences in Norway in 2008.  Returning to Sokoine University she obtained a master degree in veterinary medicine in 2009, and is now a PhD candidate at the University of Basel, Swiss Tropical and Public Health Institute.

 

 

Main objective of the study
To evaluate immunogenicity of a novel Plasmodium falciparum synthetic peptide vaccine candidate P27A administered with GLA-SE or Alhydrogel adjuvants against blood stage parasites in malaria exposed Tanzania adults

Specific objectives

♦To evaluate induction of P27A specific antibodies and determine their immunoglobulin subclasses

♦To determine if produced antibodies inhibit parasite growth invitro

♦Measuring P27A specific T cell proliferation in peripheral blood mononuclear cells

♦To measure intracellular cytokine production in vaccine induced P27A specific T cells in peripheral blood mononuclear cells